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View of the human vascular system, a complex network of veins and arteries that transport Blood and Oxygen throughout the body.
Understanding Exercise with Oxygen Therapy (EWOT)
Exercise with Oxygen Therapy (EWOT) is a protocol that involves breathing air with 95% oxygen concentration during physical activity. The combination of exercise with high oxygen concentrated air allows for optimized distribution of the oxygen to the brain, tissues, and blood.
Comparison of blood vessels undergoing vasoconstriction (left) and vasodilation (right).
Exercise induces the systemic dilation of the arteries, blood vessels and capillaries allowing for maximal dispersion of oxygen. Without exercise, vasoconstriction occurs from hyperoxia which fails to provide the maximal benefits of oxygen therapy. Combining EWOT with short intervals of hypoxic breath holds and shallow breathing encourages enhanced vasodilation and oxygen distribution.
Scientific Benefits of Oxygen Therapy
Improved Endurance
EWOT increases oxygen supply to muscles during exercise. This delays fatigue and enhances performance, allowing for longer and more intense workouts. (1, 2, 3, 4)
Faster Recovery
The increased oxygen levels from EWOT reduce lactic acid buildup in muscles. This leads to less soreness after exercise and shorter recovery times between workouts. (5, 6, 7)
Enhanced Circulation
EWOT improves blood flow throughout the body. Better circulation contributes to improved nutrient delivery throughout the system temperature regulation in extremities, increased mental alertness, and overall well-being. (8, 9, 10)
Immune Support
Improved oxygen circulation helps immune cells move more efficiently through the body. This boosts the immune system's function, enhancing your body's natural defense mechanisms. (11, 12, 13)
Cognitive Function
Increased oxygen flow to the brain during EWOT enhances cognitive functions. Users experience improvements in focus, memory, and mental clarity, leading to sharper thinking and better concentration. (14, 15, 16, 17, 18)
Sleep Quality
By regulating the body's oxygen levels, EWOT improves sleep patterns. Users enjoy more restful sleep and wake up feeling refreshed and energized. (19, 20, 21)
Concussion Recovery
Numerous studies showcase the positive effects of oxygen therapy for subjects suffering from post concussion syndrome. (22-31)
Pain Specialist & Integrative Medicine Doctor Angelique Hart presents case studies on EWOT
Dr. Tom Incledon founder of Causenta discusses the effects of EWOT on cancer patients
Dr. Heather Sandison and founder of LiveO2 Mark Squibb discuss the effects of EWOT
Subject describes recovering from a concussion 41 years after injury by using EWOT
References
Marillier, Mathieu, et al. "Oxygen Supplementation during Exercise Improves Leg Muscle Fatigue in Chronic Fibrotic Interstitial Lung Disease." Thorax, vol. 76, no. 7, July 2021, pp. 672-680.
Zinner, Christoph, et al. "Influence of Hypoxic Interval Training and Hyperoxic Recovery on Muscle Activation and Oxygenation in Connection with Double-Poling Exercise." PLOS ONE, vol. 10, no. 10, Oct. 2015, p. e0140616.
Huang, Xiaowei, et al. "Effects of Pre-, Post- and Intra-Exercise Hyperbaric Oxygen Therapy on Performance and Recovery: A Systematic Review and Meta-Analysis." Frontiers in Physiology, vol. 12, Nov. 2021, p. 791872.
Cyr-Kirk, Samuel, and François Billaut. "Hyperoxia Improves Repeated-Sprint Ability and the Associated Training Load in Athletes." Frontiers in Sports and Active Living, vol. 4, Mar. 2022, p. 817280.
Fleming, Neil, et al. "Ingestion of Oxygenated Water Enhances Lactate Clearance Kinetics in Trained Runners." Journal of the International Society of Sports Nutrition, vol. 14, Mar. 2017, p. 9.
Fichter, J., et al. "Effect of oxygen (FI02: 0.35) on the aerobic capacity in patients with COPD." Pneumologie, vol. 53, no. 3, Mar. 1999, pp. 121-126.
Chen, Y., et al. "Tissue Oxygen Saturation Is Predictive of Lactate Clearance in Patients with Circulatory Shock." BMC Anesthesiology, vol. 23, no. 1, 2023, p. 179.
Maltais, François, et al. "Effects of Oxygen on Lower Limb Blood Flow and O2 Uptake during Exercise in COPD." Medicine and Science in Sports and Exercise, vol. 33, no. 6, June 2001, pp. 916-922.
Bensaid, Sébastien, et al. "Oxygen Supplementation to Limit Hypoxia-Induced Muscle Atrophy in C2C12 Myotubes: Comparison with Amino Acid Supplement and Electrical Stimulation." Cell and Tissue Research, vol. 387, no. 2, Feb. 2022, pp. 287-301.
Layec, Gwenael, et al. "Oxygen Delivery and the Restoration of the Muscle Energetic Balance Following Exercise: Implications for Delayed Muscle Recovery in Patients with COPD." American Journal of Physiology-Endocrinology and Metabolism, vol. 313, no. 1, July 2017, pp. E94-E104.
Scheffer, Débora Delwing, and Alexandra Latini. "Exercise-Induced Immune System Response: Anti-Inflammatory Status on Peripheral and Central Organs." Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol. 1866, no. 10, Oct. 2020, p. 165823.
de Wolde, Sanne D., et al. "The Effect of Hyperbaric Oxygen Therapy on Markers of Oxidative Stress and the Immune Response in Healthy Volunteers." Frontiers in Physiology, vol. 13, Jan. 2022, p. 826163.
Schottlender, Noa, et al. "Hyperbaric Oxygen Treatment: Effects on Mitochondrial Function and Oxidative Stress." Biomolecules, vol. 11, no. 12, Dec. 2021, p. 1827.
Yang, Chunxia, et al. "The Neuroprotective Effects of Oxygen Therapy in Alzheimer's Disease: A Narrative Review." Neural Regeneration Research, vol. 18, no. 1, Jan. 2023, pp. 57-63.
Kim, Hye-Jin, et al. "Effects of Oxygen Concentration and Flow Rate on Cognitive Ability and Physiological Responses in the Elderly." Neural Regeneration Research, vol. 8, no. 3, Jan. 2013, pp. 264-269.
Wang, Zheng, et al. "Boost Your Brain: A Simple 100% Normobaric Oxygen Treatment Improves Human Motor Learning Processes." Frontiers in Neuroscience, vol. 17, July 2023, p. 1175649.
Moss, Mark C., and Andrew B. Scholey. "Oxygen Administration Enhances Memory Formation in Healthy Young Adults." Psychopharmacology, vol. 124, no. 3, Apr. 1996, pp. 255-260.
Suzin, Gil, et al. "Oxygen: The Rate-Limiting Factor for Episodic Memory Performance, Even in Healthy Young Individuals." Biomolecules, vol. 10, no. 9, Sept. 2020, p. 1328.
Long, Yun, et al. "Hyperbaric Oxygen Therapy Is Safe and Effective for the Treatment of Sleep Disorders in Children with Cerebral Palsy." Neurological Research, vol. 39, no. 3, Mar. 2017, pp. 239-247.
Wang, Zhen, et al. "Efficacy and Safety of Multiple External Therapies in Patients with Insomnia: A Systematic Review and Network Meta-Analysis." Frontiers in Neurology, vol. 15, July 2024, p. 1297767.
Hadanny, Amir, et al. "Long Term Outcomes of Hyperbaric Oxygen Therapy in Post Covid Condition: Longitudinal Follow-up of a Randomized Controlled Trial." Scientific Reports, vol. 14, no. 1, Feb. 2024, p. 3604.
Liu Z, Wang X, Wu Z, Yin G, Chu H, Zhao P. "HBOT has a better cognitive outcome than NBH for patients with mild traumatic brain injury: A randomized controlled clinical trial." Medicine (Baltimore). 2023 Sep 15;102(37):e35215. doi: 10.1097/MD.0000000000035215. PMID: 37713814; PMCID: PMC10508512.
Hadanny A, Catalogna M, Yaniv S, Stolar O, Rothstein L, Shabi A, Suzin G, Sasson E, Lang E, Finci S, Polak N, Fishlev G, Harpaz RT, Adler M, Goldman RE, Zemel Y, Bechor Y, Efrati S. "Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial." Sci Rep. 2022 Sep 23;12(1):15233. doi: 10.1038/s41598-022-19395-y. PMID: 36151105; PMCID: PMC9508089.
Ma J, Hong G, Ha E, Hong H, Kim J, Joo Y, Yoon S, Lyoo IK, Kim J. "Hippocampal cerebral blood flow increased following low-pressure hyperbaric oxygenation in firefighters with mild traumatic brain injury and emotional distress." Neurol Sci. 2021 Oct;42(10):4131-4138. doi: 10.1007/s10072-021-05094-5. Epub 2021 Feb 2. PMID: 33532950.
Linder SM, Davidson S, Rosenfeldt A, Lee J, Koop MM, Bethoux F, Alberts JL. "Forced and Voluntary Aerobic Cycling Interventions Improve Walking Capacity in Individuals With Chronic Stroke." Arch Phys Med Rehabil. 2021 Jan;102(1):1-8. doi: 10.1016/j.apmr.2020.08.006. Epub 2020 Sep 9. PMID: 32918907; PMCID: PMC7796862.
Harch PG, Andrews SR, Rowe CJ, Lischka JR, Townsend MH, Yu Q, Mercante DE. "Hyperbaric oxygen therapy for mild traumatic brain injury persistent postconcussion syndrome: a randomized controlled trial." Med Gas Res. 2020 Jan-Mar;10(1):8-20. doi: 10.4103/2045-9912.279978. PMID: 32189664; PMCID: PMC7871939.
Meehan A, Hebert D, Deru K, Weaver LK. "Longitudinal study of hyperbaric oxygen intervention on balance and affective symptoms in military service members with persistent post-concussive symptoms." J Vestib Res. 2019;29(4):205-219. doi: 10.3233/VES-180671. PMID: 31282447.
Mozayeni BR, Duncan W, Zant E, Love TL, Beckman RL, Stoller KP. "The National Brain Injury Rescue and Rehabilitation Study - a multicenter observational study of hyperbaric oxygen for mild traumatic brain injury with post-concussive symptoms." Med Gas Res. 2019 Jan-Mar;9(1):1-12. doi: 10.4103/2045-9912.254636. PMID: 30950414; PMCID: PMC6463441.
Weaver LK, Wilson SH, Lindblad AS, Churchill S, Deru K, Price RC, Williams CS, Orrison WW, Walker JM, Meehan A, Mirow S. "Hyperbaric oxygen for post-concussive symptoms in United States military service members: a randomized clinical trial." Undersea Hyperb Med. 2018 Mar-Apr;45(2):129-156. PMID: 29734566.
Tal S, Hadanny A, Sasson E, Suzin G, Efrati S. "Hyperbaric Oxygen Therapy Can Induce Angiogenesis and Regeneration of Nerve Fibers in Traumatic Brain Injury Patients." Front Hum Neurosci. 2017 Oct 19;11:508. doi: 10.3389/fnhum.2017.00508. PMID: 29097988; PMCID: PMC5654341.
Tal S, Hadanny A, Berkovitz N, Sasson E, Ben-Jacob E, Efrati S. "Hyperbaric oxygen may induce angiogenesis in patients suffering from prolonged post-concussion syndrome due to traumatic brain injury." Restor Neurol Neurosci. 2015;33(6):943-51. doi: 10.3233/RNN-150585. PMID: 26484702.
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